Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier.

Brain Aβ 1-42 concentration showed a trend for increase with brain antibody concentration across the different antibodies examined (Fig. 5H ).

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Systemic antibody clearance was increased for the M252Y and M252Y.Q309T variants, with an apparent trend between tighter mFcRn affinity at pH 7.4 and greater serum antibody clearance (Fig. 1J ).

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