The length of the G1 phase is an essential determinant of H3K27me3 landscapes across diverse cell types.

PLoS Biol · 2025 · PMC12052206 · PMID 40245079

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an increasing trendno p-value reported

We conclude they are weak nucleation sites due to an increasing trend for H3K27me2, opposite of the decreasing trend of H3K27me3 at steady state.

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trending towards significanceno p-value reported

We observed upon quantification of the ratio of H3K27me3 to H3 in a set of biological triplicates that 2i mESCs treated with Chiron-124 lost 39% global H3K27me3 modification, trending towards significance ( S8 Fig ).

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