A trending reduction in Aβ plaque burden (cumulative plaque #) was likewise observed in both the cortex and hippocampus, although these data did not reach statistical significance (Fig. 5 A, C and Supplementary Fig. 3A–D ).
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Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration.
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