The median OS from randomization was 16.1 months [95% confidence interval (CI): 12.1–19.4] for the SMART cohort and 12.5 months (95% CI: 10.9–17.0) for the IRE group, though this difference did not reach statistical significance [hazard ratio (HR), 1.39; 95% CI: 0.84–2.30; P=0.21] ( 12 ).
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