Aquaporin 4 modulation drives amyloid burden and cognitive abilities in an APPPS1 mouse model of Alzheimer's disease.

Analysis of the immunolabeled areas of Aβ42 and Aβ40 fractions revealed a highly significant increase in Aβ42 deposited in treated animals relative to Aβ40 (i.e., decreased Aβ40/Aβ42 ratio), for both the facilitator‐treated (26.9% ± 4.21%, p = 0.002) and inhibitor‐treated groups (18.2% ± 2.80%, p < 0.0001) compared to control animals (47.6% ± 6.67%), without any significant difference between the treated groups ( p = 0.151) (Figure 4E ).

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Although the inhibitor‐treated mice had a decreasing trend in the association frequency compared to control animals, this did not reach statistical significance ( p = 0.464).

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