By quantification of dot blot intensity, we found that TP53;ATRX knockout KO-1 and KO-7 cell lines exhibited a significantly higher c-circle signal compared to no polymerase controls, whereas KO-2, KO-5 and KO-6 cell lines showed a trend towards increased c-circles levels ( Fig. 1D – E ).
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ATRX mutations mediate an immunogenic phenotype and macrophage infiltration in neuroblastoma.
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