Expression patterns, prognostic significance, and immune correlations of the TNFAIP8 family in acute myeloid leukemia: a comprehensive bioinformatics analysis.

Discov Oncol · 2025 · PMC12058638 · PMID 40335819

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0590

boldest claim

The sentences

highly significantP < 0.001actually significant

TNFAIP8L3, however, presents a highly significant association (P < 0.001), suggesting that elevated BM blast counts are strongly linked to high TNFAIP8L3 expression.

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approached significanceP = 0.055so close (0.05 < p ≤ 0.1)

While TNFAIP8L2 approached significance (P = 0.055), the results for the other members (TNFAIP8, TNFAIP8L1, and TNFAIP8L3) showed no strong survival associations (P > 0.5).

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marginally significantP = 0.059so close (0.05 < p ≤ 0.1)

However, TNFAIP8 shows a marginally significant difference (P = 0.059), implying that higher WBC counts might be associated with elevated TNFAIP8 expression, though the other members do not display such associations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.