Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4+ T Cells.

Following the 2-week treatment, the anti-IL-7 Ab group showed progressive disease reduction and the disease scores were significantly lower than the baseline at week 4 with an average score of 2; the anti-IL-15 Ab group showed a trend of disease reduction but the disease scores were not significantly different from the baseline; in contrast, the disease scores of control IgG group remained the same level as the treatment baseline ( Fig. 1 A).

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