The relationship between neurofilament light chain and depressive symptoms according to cognitive status.

However, although the interaction between the NfL and CDR status did not reach statistical significance ( B = 0.003, SE = 0.002, p = 0.17), subgroup analysis revealed that among individuals with MCI, elevated NfL levels were associated with higher GDS‐15 scores ( N = 233, B = 0.004, SE = 0.002, p = 0.03).

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However, although the CDR–NfL interaction showed only a trend toward significance, exploratory simple‐slope analysis suggests that higher NfL levels may be associated with higher depressive symptoms only in individuals with MCI, whereas no significant associations were found in people with intact cognition.

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