Trace amine-associated receptors as potential targets for the treatment of anxiety and depression.

In a differential reinforcement of low-rate behavior study conducted with monkeys, RO5203648 showed a trend toward an increased number of reinforcers obtained, which also led to a significant prolongation of the inter-response time and a reduction in the response rate, effects similar to those of antidepressants ( Revel et al., 2012 ; O'Donnell et al., 2005 ).

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