Estrogen regulates duodenal calcium absorption and improves postmenopausal osteoporosis by the effect of ERβ on PMCA1b.

Sci Rep · 2025 · PMC12062487 · PMID 40341576

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did not reach statistical significanceno p-value reported

Inhibition of TRPV6 with 2-APB partially reduced duodenal calcium absorption in OVX + E2 mice ( P > 0.05), though this effect did not reach statistical significance, suggesting PMCA1b plays a dominant role in estrogen-mediated calcium absorption (Fig. 1 B).

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