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Spreading Depolarization and Seizures: End of the Beginning, or Beginning of the End?

Epilepsy Curr · 2025 · PMC12063228 · PMID 40351839

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showed a trendno p-value reported
22 An unusual cogeneration pattern of seizures and SD (“spreading convulsion”) has been detected in subarachnoid hemorrhage, 23 and the occurrence of post-injury SD showed a trend toward subsequent epileptogenesis. 24 Longitudinal clinical studies with SD detection are rare and it remains unclear whether SD acts as a driver of epileptogenesis or simply reflects the severity of the acute injury.

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