Leveraging transcriptome-wide association studies identifies the relationship between upper respiratory flora and cell type-specific gene expression in severe respiratory disease.

Considering that the eQTL model was constructed from the European(EUR)population and that the flora-associated GWAS summary data were from the EAS population, this part of the study focused only on nominally significant genes, i.e., those with uncorrected P < 0.05. 2.6 Functional enrichment analysis For a given set of genes, pathway enrichment analysis was performed via the clusterProfiler (v.4.2.2) and ReactomePA (v.1.38.0) software packages on the basis of the Gene Ontology (GO), KEGG, and Reactome pathway databases [ 47 , 48 ]. 3.

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