Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons.

2d ) showed a clear trend toward an increase in aged iNs compared to young iNs, with a p value of 0.057.

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Examination of mitochondrial impairment of iPSCsNs of aged individuals Consistent with our observations in HFs and iNs, cellular ATP levels exhibited a decreasing trend in aged iPSCsNs when comparing the four young donors to the four aged donors (Fig. 3a ).

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