Reliable detection of CNS lymphoma-derived circulating tumor DNA in cerebrospinal fluid using multi-biomarker NGS profiling: insights from a real-world study.

Biomark Res · 2025 · PMC12065147 · PMID 40346678

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.1230

boldest claim

The sentences

an expected trendp = 0.08so close (0.05 < p ≤ 0.1)

When the PCNSL and SCNSL groups were compared, no difference was observed in CSF (median 19.7 ng and 19.3 ng, respectively; p = 0.99), in contrast with an expected trend towards a higher level in plasma of SCNSL patients (median 93.5 ng and 140.0 ng, respectively; p = 0.08) (Suppl.

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did not reach statistical significancep = 0.123not close (p > 0.1)

Contrary to the MYD88 variant, the difference between PCNSL and SCNSL did not reach statistical significance ( p = 0.123).

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