Injectable Contraceptives Differentially Affect Select CD4+ HIV-1 Target Cells in the Genital Tract but Not Systemically: Implications for HIV-1 Acquisition.

The heatmap of the mITT analysis (Figure 2 ) reveals a clear trend whereby both contraceptives decreased the frequency (%) and cell numbers of most cell populations expressing HIV‐1 co‐receptors or activation markers and combinations thereof.

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There appeared to be a weak trend for frequency of cervical CD4 + cells expressing activation and integrin markers to mostly increase from D0 to 25 W, in both contraceptive arms, but more so for DMPA‐IM than NET‐EN.

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