Histopathologic Grading of Residual Tumor Predicts Survival of Intrahepatic Cholangiocarcinoma Patients Treated With Neoadjuvant Therapy: Major Pathologic Response and Its Clinical Significance.

In contrast, cPR is becoming less favored as a surrogate endpoint in recent oncological research and clinical trials for several reasons: (1) Determining a 0% RVT requires examining the entire tumor bed histologically, which is often impractical and not recommended in modern pathology practice; 39 (2) Only a small proportion of patients achieve such a response, and it is not consistently correlated with better survival outcomes in both the literature 38 and our study (only 10 cases achieved cPR and did not reach statistical significance to predict OS, Supplementary Figure 4, Supplemental Digital Content 4, http://links.lww.com/PAS/C73 ).

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