Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity.

Nat Commun · 2025 · PMC12069627 · PMID 40355419

Europe PMC DOI

hedged sentences

0.0620

closest p · 1.2× alpha

0.6600

boldest claim

The sentences

marginally significantp = 0.062so close (0.05 < p ≤ 0.1)

The changes in regression coefficients were significant in fat percentage ( p = 0.047) and marginally significant in Matsuda ( p = 0.062).

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did not reach statistical significancep = 0.66not close (p > 0.1)

While the Scandinavian T2D-discordant MZ twins also showed a positive effect size, it did not reach statistical significance (r Pearson = 0.09, p = 0.66).

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