Autoantibody Profiling in Ulcerative Colitis: Identification of Early Immune Signatures and Disease-Associated Antigens for Improved Diagnosis and Monitoring.

Int J Mol Sci · 2025 · PMC12072058 · PMID 40362323

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp -value < 2.2 × 10 −16actually significant

This comparison resulted in 196 common antigens out of 481, a highly significant overlap (odds ratio: 6.4088; 95% CI: 5.3011–7.7479; chi 2 p -value < 2.2 × 10 −16 ).

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nominally significantno p-value reported

The three-way interaction (Mesalazine: Cortisone: TNFα-blocker) yielded the highest number of nominally significant hits ( n = 22), followed by the interactions Mesalazine: Cortisone ( n = 18), Mesalazine: TNFα-blocker ( n = 17), and Cortisone: TNFα-blocker ( n = 10).

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