Drug-Based Lifespan Extension in Mice Strongly Affects Lipids Across Six Organs.

Overall, 1187 compounds in male and 729 in female of the total of 2551 annotated metabolites showed a significant trend at FDR q < 0.1 in at least one organ and sex (Appendix S2 ).

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Specifically, many neutral glycerolipids, both triacylglycerides and diacylglycerides, showed a decreasing trend across tissues, most strongly in plasma and liver (Figure 5 ).

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