IRAK3 is upregulated in rheumatoid arthritis synovium and delays the onset of experimental arthritis.

Front Immunol · 2025 · PMC12074951 · PMID 40370470

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

Concomitantly, IRAK3 −/− paws expressed higher levels of Stat3 and Ahr , two markers associated with the differentiation of Th17 cells, and significantly higher levels of FoxP3 , Il2ra , Ctla4 , and Tnfrsf1b , which are expressed by Tregs; higher levels of Il12b , Ilb , Il6 , and Il17 were also measured, although the difference did not reach statistical significance.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.