Roles of LRRK2 and its orthologs in protecting against neurodegeneration and neurodevelopmental defects.

Front Cell Dev Biol · 2025 · PMC12076734 · PMID 40371391

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did not reach statistical significanceno p-value reported

In contrast to the LRRK2 GOF variants, deletion of the LRRK2 gene caused an increase in autophagic flux in neurons cultured from postnatal day 1 rats, although this did not reach statistical significance ( Wallings et al., 2019 ).

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