Comment on "A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children".

Scand J Trauma Resusc Emerg Med · 2025 · PMC12076815 · PMID 40361229

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

failed to reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

In contrast, the original study failed to reach statistical significance ( p = 0.09) even though a large effect size was observed (a difference of 4 points in the FLACC) due to insufficient sample size (only 30 cases), highlighting the key effect of sample size on the reliability of the results.

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