Barely Significant
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A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.

mBio · 2025 · PMC12077128 · PMID 40272151

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a clear trendno p-value reported
The longitudinal analysis showed an early impact on IL-6 and IP-10 levels (3 dpi), and a clear trend to normalization by 14 dpi, with some residual inflammation remaining.

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