The longitudinal analysis showed an early impact on IL-6 and IP-10 levels (3 dpi), and a clear trend to normalization by 14 dpi, with some residual inflammation remaining.
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A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model.
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