Integrative multi-omics and Mendelian randomization analysis reveal SPP1<sup>+</sup> tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma.

Front Mol Biosci · 2025 · PMC12078150 · PMID 40376263

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did not reach statistical significanceno p-value reported

The training set ( p = 3.837e-02) showed significant associations between higher UBE2I expression and poorer survival, while the internal validation set ( p = 8.287e-02) and external validation set ( p = 4.675e-01) did not reach statistical significance ( Supplementary Figure S3A ).

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Integrative multi-omics and Mendelian randomization analysis reveal SPP1&lt;sup&gt;+&lt;/sup&gt; tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma.

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Integrative multi-omics and Mendelian randomization analysis reveal SPP1<sup>+</sup> tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma.