Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study.

Alzheimers Dement · 2025 · PMC12079641 · PMID 39711366

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did not reach statistical significanceno p-value reported

Furthermore, the intermediate LE8 group had significantly higher accumulation of WMHs over time ( β : 0.050, 95% CI: 0.004 to 0.095), whereas the poor LE8 group had even higher accumulation of WMHs, but that did not reach statistical significance ( β : 0.123, 95% CI: −0.013 to 0.260) compared to participants with ideal LE8 (Figure 2 ).

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