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NIR-Responsive ZIF-8 Metal-Organic Framework Nanohybrids with Photothermal, Antimicrobial, and Osteoinductive Properties to Prevent Implant Infection.

Macromol Biosci · 2025 · PMC12080314 · PMID 40014660

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a clear trendno p-value reported
A clear trend was observed, higher concentrations of Au@ZIF‐8 nanohybrids resulted in greater temperature increases.

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a decreasing trendno p-value reported
Additionally, in vitro cell cytotoxicity assays confirmed comparable cell cytocompatibility following 5 min of NIR irradiation (Figure 2I and Figure S3 , Supporting Information), although we observed a decreasing trend in mitochondrial activity when exposed to NIR.

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an increasing trendno p-value reported
RUNX‐2 and BMP‐2 exhibited an increasing trend, suggesting a potential for promoting osteogenesis, further supporting the nanohybrid's role in enhancing osteogenic differentiation. 4 Conclusion The synthesis of Au@ZIF‐8 nanohybrids was successfully accomplished, effectively entrapping AuNPs within the ZIF‐8 framework without compromising its structure.

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