Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson's disease.

Front Pharmacol · 2025 · PMC12081955 · PMID 40385486

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did not reach statistical significanceno p-value reported

Although the metformin group showed significant changes in biomarkers, the differences in total UPDRS scores between the two groups did not reach statistical significance.

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