Barely Significant
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B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort.

Front Immunol · 2025 · PMC12082042 · PMID 40386772

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Vaping showed the same trend towards increased IgA usage and decreased IgM, though these associations were suggestive but not significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.