Hyperactivation of mTORC1 by an endogenous <i>raga-1</i> gain-of-function mutation does not reduce lifespan in <i>C. elegans</i>.

These phenotypes could help explain why lifespan remains unchanged in the raga-1 ( viz128 [Q63L]) mutants, despite increased RSKS-1 phosphorylation. In contrast, the egIs12 [ raga-1 [Q63L]] strain exhibited decreased levels of p- RSKS-1 (T404) compared to wild type (0.26-fold, corresponding to a 73.7% reduction), although this difference did not reach statistical significance (P=0.67, mixed-effects model).

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