Zebrafish Cyp1b1 knockout alters eye and brain metabolomic profiles, affecting ocular and neurobehavioral function.

Toxicol Appl Pharmacol · 2025 · PMC12083501 · PMID 39890032

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0.0590

closest p · 1.2× alpha

0.0590

boldest claim

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near-significantp-value = 0.059so close (0.05 < p ≤ 0.1)

p-value = 0.0109) and near-significant downregulation of Cyp3c3 (adj. p-value = 0.059) in the brain suggest that these enzymes play a compensatory catabolic role in regulating retinoic acid levels in the absence of Cyp1b1.

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