Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior.

Psychopharmacology (Berl) · 2025 · PMC12084258 · PMID 39690317

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.2130

boldest claim

The sentences

a trend towards significancep = 0.056so close (0.05 < p ≤ 0.1)

There was a trend towards significance for D1 ( p = 0.056).

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showed a trendp = 0.067so close (0.05 < p ≤ 0.1)

A Male control rats showed a trend towards less time spent in the center of the open field compared to female control rats (two-way RM ANOVA main effect of sex p = 0.067; n = 15 per group).

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failed to reach significancep = 0.213not close (p > 0.1)

3 C), the CPP increase failed to reach significance at either exposure concentration of toluene compared to controls (two-way RM ANOVA main effect of drug: F 2,42 = 1.603 p = 0.213; test day: p = 0.289; drug x test day interaction: p = 0.806).

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