Antioxidant and Analgesic Effect of Melatonin Involving Sirtuin 1: A Randomised Pilot Clinical Study

J Cell Mol Med · 2025 · PMC12087297

Europe PMC

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showed a trendno p-value reported

SIRT1 plasma levels in the melatonin‐treated group, although not reaching statistical significance, showed a trend in increase from T0 to T1 and T2 (Figure 4 ; 5.68 (1.47–51.3) ng/mL, 17.7 (1.69–103.8) ng/mL, 16.2 (3.24–61.4) ng/mL at T0, T1 and T2, respectively).

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