The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to amyloid beta and phosphorylated tau-induced neuronal dysfunction.

Alzheimers Dement · 2025 · PMC12089071 · PMID 40019008

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showed a trendno p-value reported

WT and tau KO neurons with glial support showed a trend toward an increased spike rate in tau KO iNeurons (Figure S3F ).

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