Neuron-specific enolase in patients with acute and chronic schizophrenia, diversity of approaches: marker of neuronal death, neurodegeneration or neurodevelopmental theory in schizophrenia? a single-center case-control study.

A weak negative correlation was observed between NSE concentrations and the overall SANS score (R=-0.12, p=0.38) ( Figure 2A ) and a weak positive correlation was noted between NSE concentrations and the overall SAPS score (R=0.11, p=0.42) ( Figure 2B ), but the results did not reach statistical significance.

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In our study, we also observed a positive trend in terms of the relationship between NSE concentrations and the severity of positive symptoms (i.e., the severity of schizophrenia exacerbation).

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