Dysfunctional mesocorticolimbic circuitry in cluster headache.

J Headache Pain · 2025 · PMC12090487 · PMID 40394469

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hedged sentence

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

tendency towards significancep = 0.056so close (0.05 < p ≤ 0.1)

Results Results showed that chronic CH patients exhibited reduced ventral tegmental area (VTA) activity and a tendency towards significance ( p = 0.056) for an increased medial prefrontal cortex (mPFC) responsiveness during reward anticipation, alongside a significant decrease in mPFC activity during reward outcomes.

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