Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader.

ChemMedChem · 2025 · PMC12091851 · PMID 39973224

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showed a trendno p-value reported

The alkyl spacer‐based compounds revealed some unexpected results: while the C5 spacer (compound 1h ) did not reduce HDAC1 levels, PROTACs with both shorter and longer spacers showed a trend toward significant HDAC1 degradation.

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