Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials.

Nat Aging · 2025 · PMC12092243 · PMID 40155777

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0.0590

closest p · 1.2× alpha

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boldest claim

The sentences

showed a trendP = 0.059so close (0.05 < p ≤ 0.1)

The individual fluid versus neuroimaging tau biomarker models did not differ from each other (plasma p-tau217 versus tau-PET MTL , P = 0.322; plasma p-tau217 versus tau-PET NEO , P = 0.750), while the performance of tau-PET MTL showed a trend toward better performance than tau-PET NEO ( P = 0.059).

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