Effects of sodium/glucose cotransporter 2 inhibitors on the coagulation profile in patients with coronary-artery disease and type 2 diabetes mellitus: a retrospective cohort study.

In our study, patients receiving SGLT2i treatment exhibited altered coagulation features that were characterized by a decreasing trend in D-dimer levels, but unchanged PT, suggesting that the extrinsic coagulation pathway was not significantly activated and that there were no thrombosis events.

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These findings suggested that while PT remained largely unchanged with SGLT2i treatment, the interaction effect between time and group ( P = 0.087) was close to being significant, indicating the need for further analysis of the potential impact of group.

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These findings suggest that SGLT2i treatment may reduce D-dimer levels, although the effect did not reach statistical significance and further analysis of potential impacts is needed.

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