Single-cell analysis reveals tumour size as a key driver of immune cell profile alterations in primary breast tumours and corresponding lymph nodes.

The lymph node clusters LN1-LN4 were significantly correlated with lymph node status ( p = 0.01) and showed a trend towards differences in primary tumour and metastatic size ( p = 0.071) but not with other clinical parameters such as metastasis size and primary tumour size (Fig. 3b, e, f , Supplementary Fig. 3B ).

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