Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX.

When compared, no significant differences in lesion scores were observed between individual pigs nor between groups A and B (Figure S4A). Immune responses Serum levels of ASFV-specific antibodies ( Figure 6 (A)) were above the cut-off in 4 pigs in Group A at 14 dpi and in all animals by 21 dpi. The numbers of IFN-γ producing cells in pigs from Group A showed a trend to be higher after genotype II stimulation, followed by genotype I and lowest for genotype IX stimulation ( Figure 6 (E), S5A-D).

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