Characterizing pleiotropy among bipolar disorder, schizophrenia, and major depression: a genome-wide cross-disorder meta-analysis.

Psychol Med · 2025 · PMC12094657 · PMID 40357923

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0.0003

closest p · 0.0× alpha

0.0003

boldest claim

The sentences

nominally significantp = 0.0003actually significant

Additionally, we identified one variant (rs2588469) that showed genome-wide significant pleiotropic effects (PLEIO p = 1.18 × 10 −8 ), but showed only nominally significant associations with the three disorders investigated (BP: beta = −0.056, p = 0.0003; MDD: OR = 0.98, p = 9.9 × 10 −5 ; SCZ OR = 1.062, p = 0.0008).

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