Kynurenine pathway metabolite alterations in Down syndrome and Alzheimer's disease.

Alzheimers Dement · 2025 · PMC12094884 · PMID 40399749

Europe PMC DOI

hedged sentence

0.0740

closest p · 1.5× alpha

0.0740

boldest claim

The sentences

did not reach statistical significancep = 0.074so close (0.05 < p ≤ 0.1)

However, although a decrease in AA was also observed in the AD group, this did not reach statistical significance ( p = 0.074), suggesting a potential difference in the regulation or modulation of neuroprotective pathways between these two groups.

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