Mpox multiprotein virus-like nanoparticle vaccine induces neutralizing and protective antibodies in mice and non-human primates.

After the prime immunization the difference in neutralization between the sera from mice that received the combination of VLPs and the sera from mice that received the combination of SPs or MVA was highly significant, whereas there were smaller differences from those that received either individual VLPs or the chimeric VLP (Fig. 2d ).

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Also, mice boosted with the three SPs lost slightly more weight from days 5–8 than those boosted with the three VLPs but the difference did not reach statistical significance.

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