Reduced immune response to SARS-CoV-2 infection in the elderly after 6 months.

Front Immunol · 2025 · PMC12098630 · PMID 40416973

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did not reach statistical significanceno p-value reported

Although the majority of these differences did not reach statistical significance ( Supplementary Figure 3 ). 4 Discussion Older people are highly vulnerable to SARS-CoV-2 and its variants, mainly due to their poor antibody response ( 29 ).

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an increasing trendno p-value reported

In the meantime, both CD69 + and CD38 + T cells decreased, but the frequencies of PD-1 + and CTLA-4 + of CD4 + and CD8 + T cells showed an increasing trend.

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a decreasing trendno p-value reported

The proportion of NKT cells in all age groups showed a decreasing trend ( Figure 4L ). 3.4 SARS-CoV-2-specific cellular immunity of the elderly after infection 3.4.1 Activation of CD4 + /CD8 + T cells decreased in older people To characterize the specific cellular immune effects and immune memory response in older people, PBMCs from the elderly at 3m pi and 6m pi were stimulated with the peptide pool of S protein of BA.5 variants.

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