Pathogenicity of commensal gut biofilm in prefrail aging.

NPJ Biofilms Microbiomes · 2025 · PMC12098755 · PMID 40404666

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a notable trendno p-value reported

4B ) exhibited a notable trend towards increased expression in prefrail versus robust individuals.

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failed to reach statistical significanceno p-value reported

While such trends failed to reach statistical significance when considered alone—except in the case of TNF and IL6 —the PCA ordination plot demonstrated a clear shift in the transcriptome of epithelia exposed to bacteria from prefrail individuals compared to younger individuals (Fig. 4C , PERMANOVA P = 0.007).

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