PDGFRα/β heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation.

However, normalization of ligand-stimulated phospho-PDGFR levels to unstimulated phospho-PDGFR levels for each sample indicated lower relative induction approaching significance for PDGFRβ homodimers following 5 min of ligand stimulation in the PDGFRαV1/βV2 cell line compared to this same timepoint in the PDGFRβV1/βV2 cell line (Supplementary Fig. 11C ), indicating that PDGFRα/β heterodimers may indeed serve as ligand sinks.

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