Importance of blood pressure lowering in patients with direct oral anticoagulant-associated intracerebral haemorrhage in the acute phase and for secondary prevention.

26 A systematic review and meta-analysis comparing nicardipine and clevidipine came to the conclusion that SBP goals were reached faster with clevidipine, although this did not reach statistical significance. 32 Clevidipine was also used in the recently announced INTEnsive care bundle with blood pressure Reduction in Acute Cerebral haemorrhage Trial (INTERACT3), but outcomes specifically in relation to different agents are not yet available. 14 Intensive BP lowering in antithrombotic-associated ICH: Current evidence Observational studies support the importance of BP control in reducing the risk of haematoma expansion in DOAC-ICH.

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