Nevertheless, the activation markers CD25 and CD69 and the Fc receptor CD16, required for antibody-dependent cellular cytotoxicity, showed a trend towards decreased expression for the thawed HSPC-NK cell product (Fig. 2 A, B).
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Good manufacturing practice production of an off-the-shelf CD34<sup>+</sup> progenitor-derived NK cell product with preserved anti-tumor functionality post-infusion in NOD/SCID/IL2Rg<sup>null</sup> mice.
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