Safety and efficacy of low-temperature RA-flush solution in patients with moderate-to-severe calcified lesions (LOTA-II): a randomized, double-blind, multicenter study.

Another interesting finding from this study is as follows: the incidence of 1-year clinically driven TVR in the low-temperature group showed a downward trend (although it did not reach statistical significance), which may indicate that the local protection of hypothermia during RA may affect the long-term prognosis.

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